Renal dose adjustment guidelines for antimicrobials crrt. Continuous hemodialysis assumes an ultrafiltration rate of 2lh and dialysate flow rate of 1lh with cvvhdf and residual native gfr of cancidas caspofungin includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Topics az slideshows images quizzes supplements medications. A catalogue record for this book is available from the british library. This translational reference takes an indepth look at ckd while excluding coverage of dialysis or transplantation, which are both well detailed in other textbooks and references. Caspofungin inn brand name cancidas worldwide is a lipopeptide antifungal drug from. Uclh dosage adjustment for cytotoxics in renal impairment version 3 updated january2009 page 2 of 24 dosage adjustment for cytotoxics in renal impairment this table is a guide only. Cancidas caspofungin dosing, indications, interactions. Drug dosing in renal disease matthew p doogue, 1,2 thomas m polasek 1. Caspofungin cancidas an antifungal drug healing is.
Easytoread tables put the information physicians need when determining dosages for more than 450 drugs at their fingertips. The pharmacists will automatically adjust the doses of any of the antimicrobials included in the protocol according to the estimated creatinine clearance generally using the cockroftgault equation for patients. Jul 31, 2007 containing information on over 450 drugs, the fifth edition of drug prescribing in renal failure is the most extensive collection of drug dosing information ever published for patients with impaired renal function. This guide succeeds at providing busy healthcare providers with updated and evidencebased information on dosing and monitoring commonly used medications in patients with renal dysfunction.
Empirical therapy for presumed fungal infections in febrile, neutropenic patients. Currently, three echinocandins, anidulafungin, caspofungin and micafungin are licensed for clinical use in various indications. Oct 01, 2007 the maintenance dosage of caspofungin was adjusted to 35 mg daily for patients with moderate hepatic insufficiency, defined as a childpugh score of 79. Estimated crcl mlmin recommended dosage regimen for teflaro 50 no dosage adjustment necessary 30 to. It is nondialysable, and studies in patients with moderate chronic kidney disease gfr renal disease comprehensively investigates the physiology, pathophysiology, treatment, and management of chronic kidney disease ckd. Drug dosing adjustments in patients with chronic kidney disease myrna y. Caspofungin neonatal king edward memorial hospital. Drug prescribing in renal failure, 5th edition acp books. Cvvhd removes solutes including drugs via diffusion. Common and rare side effects for cancidas intravenous. Drug dosing and renal toxicity in the elderly patient. Uhn division of nephrology ukidneys nephrology community.
Normal dose based on indication, titrate according to target serum level. As the field moves forward so also do the therapeutic opportunities, and pitfalls. The dosage and duration of cancidas treatment for each indication are as follows. The renal drug handbook third edition edited by caroline ashley and aileen currie uk renal pharmacy group foreword by. For oncedaily dosing, draw a single random level 8 to 12 hours after dose given adjustments are made based on a published hartford nomogram. Caspofungin cancidas is an antifungal drug that inhibits fungal cell wall synthesis and is used to treat candidiasis and invasive aspergillosis. Caspofungin, an echinocandin antifungal, inhibits formation of b 1, 3 glucan of the fungal cell wall. Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary. This medication is given by injection into a vein as directed by your doctor, usually once a day over 1 hour. Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in. The data base for rational guidelines to safe, efficacious drug prescribing in adults with renal insufficiency are presented in tabular form. Renal dose adjustment guidelines for antimicrobials. Drug dosing in chronic kidney disease, medication dosing in chronic kidney disease, renal dosing, antibiotic dose adjustments in impaired renal function, antihypertensive dose adjustments in impaired renal function, analgesic dose adjustments in impaired renal function, ace inhibitor and angiotensin receptor blocker adjustments in impaired.
Cancidas caspofungin dosing, indications, interactions, adverse. For seizure indication, administer q12h but may require. Empirical therapyfor presumed fungal infections in febrile neutropenic patients administer asingle 70mg loadingdose on day 1, followed by 50mg once daily thereafter. Pharmacology and metabolism of anidulafungin, caspofungin and. Dglucan synthase and thereby disturbing the integrity of the fungal cell wall. This page includes the following topics and synonyms. There was no dosage adjustment for patients with renal dysfunction.
Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous. Dosage adjustment for cytotoxics in renal impairment. Usual dose is 30 mg subcutaneously every 12 hours, the usual duration of administration is 7 to 10 days. Renal dosage adjustment guidelines for antimicrobials. Caspofungin is a valuable new antifungal agent with a novel mechanism of action. Estimating renal function in paraplegia intechopen. Avoid use with aliskiren in patients with renal impairment egfr 60 mlmin1. Pharmacology and metabolism of anidulafungin, caspofungin. Dosing information in renal impairment 3 5 netilmicin 2 mgkg q 8 hr once daily dosing 5090 100% normal dose q 8 hr 1050 100% normal dose q 1224 hr 80 6. Candidemia and the following candida infections intraabdominal abscesses, peritonitis, and pleural space infections.
Cancidas is a sterile, lyophilized product for intravenous iv infusion that contains a semisynthetic lipopeptide echinocandin compound synthesized from a fermentation product of glarea lozoyensis. This book is distributed under the terms of the creative commons attribution 4. Acp books, here is the classic pocket guide to drugdosing for patients with impaired renal functionin a revised and updated new edition. Pharmacokinetic, summary of product characteristics spc, relevant pharmaceutical company data and various references have been. Fbn 2459 and the north carolina nurses association. This new book addresses the persistent and challenging problem of dosing medications for patients with renal insufficiency and dysfunction. Direct oral anticoagulants doacs are nonvitamin k antagonists that have now been approved for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation nvaf, the acute and extended treatment of venous thromboembolism, and the prevention of venous thromboembolism after total knee or hip. When should providers begin to consider modifying drug dosing in patients with chronic kidney disease ckd and esrd. Enoxaparin outcomes in patients with moderate renal impairment. Caspofungin is administered once daily by slow intravenous infusion and is used to treat infections caused by candida spp. Drug dosing in chronic kidney disease, medication dosing in chronic kidney disease, renal dosing, antibiotic dose adjustments in impaired renal function, antihypertensive dose adjustments in impaired renal function, analgesic dose adjustments in impaired renal function, ace inhibitor and angiotensin receptor blocker adjustments. Cancidas caspofungin acetate is a glucan synthesis inhibitor. What is the most important information i should know about caspofungin cancidas.
Once estimated gfr egfr indicates stage 3 or higher ckd dosing intervals, or of both should be considered. Duration of treatment should be based upon the severity of the underlying disease, recovery from immunosuppression, and clinical response. The fifth edition of 2007 has been significantly expanded by dosage tables for children. In plasma, caspofungin concentrations fell below the limit of quantitation after 68 days post dose, while radiolabel fell below the limit of quantitation at 22. When a patient is initiated on crrt, antimicrobial therapy often requires adjustment to ensure adequate drug concentrations are achieved. In vitro activity was assessed using microdilution broth susceptibility testing. Factors for determining drug dosage are given in easytoread tables.
Apr 28, 2011 echinocandins represent the newest class of antifungal agents. Drug dosing adjustments in patients with chronic kidney disease. This is a simplified table that lists the most common dosing in individuals with norma renal function, normal weight, and lack of concomitant interacting medications eg, p glycoprotein inhibitors or inducers. The results reveal a disturbing rate of major bleeding in 1 of 4. Atacand candesartan dosing, indications, interactions. Dosage of teflaro in patients with renal impairment.
When cancidas is coadministered to adult patients with other inducers of hepatic cyp enzymes, such as efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine, administration of a daily dose of 70 mg of cancidas should be considered see dosage and administration 2. The division of nephrology is one of the largest nephrology programs in canada, encompassing treatment of chronic kidney disease ckd with dialysis and transplantation, general nephrology, subspecialty clinics, teaching and research. Drugs in renal failure is a topic covered in the harriet lane handbook to view the entire topic, please sign in or purchase a subscription the harriet lane handbook app and website provides pediatric diagnosis and treatment, pediatric management algorithms, and pediatric drug formulary from experts at johns hopkins university. Caspofungin coadministration reduces tacrolimus exposure by approximately 20%, and dosage adjustments may be required. Dosing guidelines book school of medicine university of. When cancidas is coadministered to adult patients with other inducers of hepatic cyp enzymes such as nevirapine, efavirenz, carbamazepine, dexamethasone, or phenytoin, administration of a daily dose of 70 mg of cancidas should be considered see drug interactions 7. Feb 11, 2019 adult patients on rifampin should receive 70 mg of cancidas once daily. Recommended dosage is for pediatric patients 1 to 17 years of age with normal renal function.
Orlando regional healthcare is an approved provider of continuing nursing education by florida board of nursing provider no. The renal drug handbook has developed into an essential resource for nephrologists, specialist nurses and pharmacists engaged in the care of these patients. Micafungin versus caspofungin for treatment of candidemia and. In patients with renal artery stenosis, monitor renal function. Direct oral anticoagulants and renal dosing college of. No dosage adjustment is necessary based on renal impairment see section 5. Cancidas 50 mg formerly caspofungin msd summary of. Renal drug handbook 3rd edition general intensive care unit. Renal dosage adjustment guidelines for antimicrobials the pharmacists will automatically adjust the doses of any of the antimicrobials included in the protocol according to the estimated creatinine clearance generally using the cockroftgault equation for patients. Find patient medical information for cancidas intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The efficacy of cancidas at the 150 mg daily dose was not significantly better than the efficacy of the 50mg daily dose of cancidas.
What should i discuss with my health care provider before receiving caspofungin cancidas. Refer to uptodate topics on af, vte treatment, vte prophylaxis, and doac dosing for possible changes based on. The dosage and length of treatment are based on your medical. Ibwideal body weight use tbw if ibw is greater than patients weight abwadjusted body weight tbwtotal body weight. Bennett division of nephrology and hypertension, oregon health and science university, portland, oregon. The renal drug handbook the st georges hospital, adult critical. The information on dosage adjustments in renal impairment given in this book is based on. Dosing in renal insufficiency tables adult and adolescent. The information contained in this book has been compiled. Drug dosing adjustments in patients with chronic kidney. Renal function declines with age as a result of the anatomical and physiological changes that occur with aging.
Currently, there is no accepted standard method for determining renal dosing regimens for patients with paraplegia, and data on estimating renal function in such population is scarce. Usual dose is 40 mg subcutaneously per day, the usual duration of administration is 7 to 10 days. Because renal function deteriorates with age, even in the seemingly healthy patient, clearance of renally excreted and metabolized drugs may be markedly impaired in the elderly patient. Caspofungin acetate is the first antifungal medication of the echinocandins class to. Oct 22, 2019 adult and adolescent opportunistic infection table 7. Three isolates, one with a low and two with elevated caspofungin mics, were chosen and mice were infected with c. Cancidas 9344307 caspofungin acetate for injection 70 mg on days 1 through 10, and also received two 3 mgkg doses of cyclosporine 12 hours apart on day 10, developed transient elevations of alanine transaminase alt on day 11 that were 2 to 3 times the upper limit of normal uln. Find information about common, infrequent and rare side effects of cancidas intravenous.
It is a member of a new class of antifungals termed the echinocandins. Fenofibrate and its active metabolite, fenofibric acid, are primarily excreted by the kidneys. The efficacy of doses higher than 50 mg daily in the other adult patients for whom cancidas is indicated has not been evaluated. Chapter 3 renal drug dosing concepts 25 role of renal drug transporters all aspects of drug transport in the kidney may be affected by coadministration of other substances, even in patients with normal renal function. Rifampin reduces caspofungin blood levels by approximately 30%, and the daily dosage of caspofungin should be increased from 50. Renal clearance of parent drug is low approximately 0. What are the possible side effects of caspofungin cancidas. Cancidas caspofungin acetate for injection, for intravenous use. The effects of other variables that may influence drug dosing in renal disease, such as changes in urine ph and the role of drug transporters for secretion, are beyond the scope of this article. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Drug dosing and renal toxicity in the elderly patient ali j. Evaluation of drug dosing in renal failure article pdf available in iosr journal of pharmacy and biological sciences volume 11issue 5 ver. Bennetts drug prescribing in renal failure has been the best pocket book for drug prescribing in patients with renal insufficiency and dialysis since the first edition in 1987. Munar, pharmd, bcps, and harleen singh, pharmd oregon state university college of pharmacy, portland, oregon.
A small amount of caspofungin is excreted unchanged in urine approximately 1. Cancidas caspofungin acetate dose, indications, adverse. Recommended dosage regimen for pediatric patients 1 to 17 years of age with s. Dosing recommendations for drugs used to treat or prevent opportunistic infections that require dosage adjustment in patients with renal insufficiency. Rifampin reduces caspofungin blood levels by approximately 30%, so the daily dosage of caspofungin should be increased from 50 mg to 70 mg if. Welcome to nephrology at the university health network. Medscape fungal infection dosing for cancidas caspofungin. Use of ideal body weight ibw for determining the mgkg dose appears to be more accurate than dosing on the basis of total body weight tbw. Rifampin reduces caspofungin blood levels by approximately 30%, and the daily dosage of caspofungin should be increased. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry.
Drug dosing in chronic kidney disease and dialysis. For obese patients total body weight 20% over ideal body weight, dosage requirement may best be estimated using an. Invokana canagliflozin significantly improved renal. Cancidas, inncaspofungin as acetate european medicines. Dosage adjustment for pediatric patients with renal impairment has not been established. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents. Current medical literature was extensively surveyed to provide as much specific information as possible. For additional information on cancidas, please visit cancidas. Duration of therapy is dependent on clinical response.
This study evaluated the safety of enoxaparin administered in recommended doses to patients with moderate renal impairment. Caspofungin is the first of a new class of antifungal agents, the echinocandins, that inhibit the synthesis of the fungal cell wall component beta1,3dglucan. Further information can be found in clinical pharmacology textbooks such as begg, 4 goodman and gilman, and cervelli 14 or the primary literature. Therefore, in case of liver impairment the dose needs to be reduced.